Top-seed Novak Djokovic fought through the discomfort in his left shoulder to beat Jo-Wilfried Tsonga 6-3, 6-4, 7-6. More than once Djokovic grabbed his shoulder, the one he fell on in his previous match.
Earlier in the day Australian Open champion Stan Wawrinka kept up his bid for a second Grand Slam singles title when he advanced to the fourth round with a 6-3, 6-3, 6-4 win over Denis Istomin. The fifth-seeded Wawrinka, who had 12 aces in the match, will play Feliciano Lopez in the next round. That's because Lopez eliminated John Isner 6-7, 7-6, 7-6, 7-5. The ninth seeded Isner was the last American singles player at Wimbledon.
This marks the first time in more than a century, no American singles players reached the round of 16 at Wimbledon. Not since 1911 had zero U.S. men or women been in the round of 16 at Wimbledon, according to the International Tennis Federation. That year, no American women even entered the tournament and only three men did.
Three of the top four women's seeds have now been eliminated with the loss by No. 4 Agnieszka Radwanska. The 2012 Wimbledon runner-up lost in the fourth round to 22nd-seeded Ekaterina Makarova of Russia 6-3, 6-0. The top two seeds, Serena Williams and Li Na, lost last week.
Former World No.1 Caroline Wozniacki lost her fourth-round match to unseeded Barbora Zahlavova Strycova 6-2, 7-5. This is the first time in three meetings that the 16th-seeded Wozniacki has lost to the Czech.
Eugenie Bouchard, the 13th-seed, has advanced by beating the woman who ousted top seed Serena Williams, Alize Cornet. Bouchard won the last four games to reach the Wimbledon quarterfinals with a 7-6, 7-5 win over Cornet. Bouchard is the only woman this year to have advanced to the semifinals of both Grand Slam tournaments earlier this year.
And Madison Keys of the U.S. has withdrawn from her uncompleted third-round match because of a left thigh injury. The 30th-seeded Keys won her first tour title at the Eastbourne grass-court Wimbledon warm-up.