The cartoon, which was published in Thursday's edition of the Sacramento Bee, depicts Texas Gov. Rick Perry declaring that "business is booming in Texas." The next frame shows a silhouette of Perry standing in front of what is supposed to be the plant exploding.
Perry is flanked by a banner that declares "Low taxes!" and "Low Regs!" The cartoonist, Jack Ohman, said in a blog on the Bee's website that his artwork aimed to expose Perry's claims as dangerous.
"What I am trying to do is make readers think about an issue in a striking way," Ohman wrote. "The question is whether it is tasteless or not. My answer, respectfully, is that it isn't."
At least 15 people were killed, hundreds were injured and scores of homes and buildings were damaged in the April 17 explosion.
You can see the cartoon at sacbee.com.