Amanda Knox interview airs on ABC 7

Amanda Knox was convicted, then acquitted of Meredith Kercher's murder. Photo: Associated Press

More than a year and a half after walking out of an Italian court a free woman, and just weeks after another judge tossed out her acquittal in the murder of her roommate, Amanda Knox spoke out on national television for the first time.

In an interview that aired on ABC Tuesday night at 10 p.m., Knox spoke at length about the four years she spent inside an Italian prison, her battle in Italian courts, her conviction and eventual acquittal of the murder of Meredith Kercher and, most recently, the overturning of that acquittal.

In a new interview with People Magazine, Knox said that she's sometimes "paralyzed" with anxiety stemming from the 2007 death of Kercher and the legal proceedings that saw her convicted then acquitted.

"When Meredith was murdered and I was arrested, it was so shocking. It was paralyzing. Everything toppled," said Knox, who returned home to Seattle in 2011 after four years in an Italian prison.

Kercher was murdered in 2007 inside the apartment that she and Knox shared in Perugia. Italian prosecutors have long insisted that Knox and her then-boyfriend, Rafael Sollecito, stabbed Kercher to death in her bedroom. Knox's defenders said that police bungled the case from the start, tainted the crime scene and disrupted DNA evidence.

Since returning to the United States in 2011, Knox has been studying at the University of Washington. Her status was turned upside down on March 25, though, when Italy's highest court overturned her not guilty verdict and ordered a new trial.

Many are questioning whether it was smart for Knox to speak out.

Criminal Defense Attorney Richard Finci says the simple conversation with Sawyer cane turn up in court - as a confession.

"Anything she says and maybe she says things now...that are contradictory to what she says years earlier," Finci explained. "...there are so many different ways you could damage your case in speaking to the press"

Tuesday's interview coincides with the release of Knox's new memoir, "Waiting To Be Heard."

In the memoir, she also details how she eventually became suicidal and thought of swallowing shards of glass or suffocating herself with a garbage bag.

The Associated Press contributed to this report.