The puppies died despite efforts by shelter workers to provide them nourishment, including pairing them with a nursing mother cat.
The puppies were found earlier this week in two bags.
Because the puppies died, their abandonment could be prosecuted under cruelty statutes. The misdemeanor provides for a jail sentence and a fine, or both.
The Danville Area Humane Society is offering a reward of up to $1,000 for information leading to the arrest and conviction of anyone responsible in the abandonment.